Retinitis Pigmentosa Stem Cell Treatment

Stem Cell Treatmtent for Retinitis Pigmentosa

 
stem cell treatment for retinitis pigmentosa

Stem Cell Treatment for Retinitis Pigmentosa

Retinitis Pigmentosa treatments using stem cells is now an option...

Retinitis pigmentosa is a group of genetic eye conditions that leads to incurable blindness. In the progression of symptoms for Retinitis pigmentosa, night blindness generally precedes tunnel vision by years or even decades. Many people with Retinitis pigmentosa do not become legally blind until their 40s or 50s and retain some sight all their lives. Others go completely blind from Retinitis pigmentosa, in some cases as early as childhood. Progression of Retinitis pigmentosa is different in each case.

Retinitis pigmentosa is a type of progressive retinal dystrophy, a group of inherited disorders in which abnormalities of the photoreceptors (rods and cones) or the retinal pigment epithelium of the retina lead to progressive visual loss. Affected individuals first experience defective dark adaptation or nyctalopia (night blindness), followed by reduction of the peripheral visual field (known as tunnel vision) and, sometimes, loss of central vision late in the course of the disease.

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Stem Cell Treatment for Retinitis Pigmentosa

Streaming NIH database and search results:

Signaling networks of retinal ganglion cell formation and the potential application of stem cell-based therapy in retinal degenerative diseases. Hum Gene Ther. 2016 Jul 27; Authors: Wu N, Wang Y, Yang L, Cho KS Abstract Retinal degenerative diseases such as age-related macular degeneration, retinitis pigmentosa, and glaucoma result in permanent loss of retinal neurons and vision. Stem cell therapy could be a novel treatment strategy to restore visual function. Generation of stem cell-derived retinal neurons for replacement therapy is an ideal approach. Thus, it is crucial to elucidate the molecular mechanisms that regulate the development of retinal progenitor cells and subsequent generation of specific retinal neurons. Here, we summarize recent findings concerning the intrinsic and extrinsic factors that regulate RPC maintenance and differentiation, especially on the transcriptional factors and extrinsic signals. Understanding these mechanisms is critical for designing strategy to generate specific retinal cells such as retinal ganglion cells for replacement treatment of glaucoma and other optic neuropathies. PMID: 27466076 [PubMed - as supplied by publisher]
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