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Stem Cell Treatment for Rejuvenation

Related Articles Turning back time with emerging rejuvenation strategies. Nat Cell Biol. 2019 01;21(1):32-43 Authors: Mahmoudi S, Xu L, Brunet A Abstract Ageing is associated with the functional decline of all tissues and a striking increase in many diseases. Although ageing has long been considered a one-way street, strategies to delay and potentially even reverse the ageing process have recently been developed. Here, we review four emerging rejuvenation strategies-systemic factors, metabolic manipulations, senescent cell ablation and cellular reprogramming-and discuss their mechanisms of action, cellular targets, potential trade-offs and application to human ageing. PMID: 30602763 [PubMed - indexed for MEDLINE]